Laser-induced release of encapsulated materials inside living cells

Andre G. Skirtach, Almudena Muñoz Javier, Oliver Kreft, Karen Köhler, Alicia Piera Alberola, Helmuth Möhwald, Wolfgang J. Parak, Gleb B. Sukhorukov

Research output: Contribution to journalArticlepeer-review

459 Citations (Scopus)

Abstract

(Figure Presented) Escape route: The laser-initiated release of fluorescently labeled polymers from polyelectrolyte-multilayer microcapsules is demonstrated inside living cancer cells. A polymer is incorporated in capsules with metal nanoparticles in their walls, which serve as light-absorbing centers. The capsules are internalized by cells and near-infrared light ruptures the walls of the capsules, thus releasing the content into the cells.

Original languageEnglish
Pages (from-to)4612-4617
Number of pages6
JournalAngewandte Chemie - International Edition
Volume45
Issue number28
DOIs
Publication statusPublished - 10 Jul 2006
Externally publishedYes

Keywords

  • Drug delivery
  • Multilayers
  • Nanoparticles
  • Photoactivation
  • Polymers

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