Key Parameters for Size- and Shape-Controlled Synthesis of Vaterite Particles

Yulia I. Svenskaya, Hassan Fattah, Olga A. Inozemtseva, Anna G. Ivanova, Sergei N. Shtykov, Dmitry A. Gorin, Bogdan V. Parakhonskiy

    Research output: Contribution to journalArticlepeer-review

    52 Citations (Scopus)

    Abstract

    Calcium carbonate (CaCO3) has attracted scientific attention due to its essential role in both inorganic and bioorganic chemistry. Vaterite is the least thermodynamically stable CaCO3 polymorph and has elicited great interest as an advanced biomaterial for tissue engineering, drug delivery, and a broad range of personal care products. Numerous methods of vaterite particle synthesis with different sizes and morphologies have highlighted the submicron porous particles of spherical or ellipsoidal shape as the most useful ones. In this regard, the current study is aimed at development of a reliable method for synthesis of such structures. Herein, submicron vaterite particles are synthesized by dropwise precipitation from saturated sodium carbonate and calcium chloride solutions in the presence of ethylene glycol while manipulating the concentration ratios of reagents. We demonstrate that our novel technique named "dropwise precipitation" leads to changing calcium concentrations in the reaction solution at each moment affecting the crystallization process. The proposed technique allows routine obtainment of vaterite particles of a required shape, either spherical or ellipsoidal, and a controlled size in the range from 0.4 to 2.7 μm and (0.4 × 0.7) to (0.7 × 1.1) μm, respectively. The key parameters influencing the size, shape, and percent of vaterite fraction for synthesized CaCO3 particles are discussed.

    Original languageEnglish
    Pages (from-to)331-337
    Number of pages7
    JournalCrystal Growth and Design
    Volume18
    Issue number1
    DOIs
    Publication statusPublished - 3 Jan 2018

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