Is myelin basic protein a potential biomarker of brain cancer?

M. G. Zavialova, V. E. Shevchenko, E. N. Nikolaev, V. G. Zgoda

    Research output: Contribution to journalArticlepeer-review

    3 Citations (Scopus)

    Abstract

    Myelin basic protein is a potential biomarker for the central nervous system diseases in which the myelin sheath is destroyed. Using pseudo-selected reaction monitoring and the method of standard additions, we have measured the myelin basic protein level in the cerebrospinal fluid of patients with neurotrauma (n = 6), chronic neurodegenerative diseases (n = 2) and brain cancer (n = 5). Myelin basic protein was detected only in four out of five cerebrospinal fluid samples of patients with brain cancer. The cerebrospinal fluid myelin basic protein level ranged from 3.7 to 8.8 ng ml−1. We suggest that monitoring of myelin basic protein in cerebrospinal fluid can serve as a diagnostic test for the brain cancer.

    Original languageEnglish
    Pages (from-to)192-196
    Number of pages5
    JournalEuropean Journal of Mass Spectrometry
    Volume23
    Issue number4
    DOIs
    Publication statusPublished - 1 Aug 2017

    Keywords

    • brain cancer
    • cerebral spinal fluid
    • myelin basic protein
    • Proteomics
    • pseudo-selected reaction monitoring

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