Is alternative splicing of mammalian genes conserved?

R. N. Nurtdinov, A. A. Mironov, M. S. Gelfand

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The conservation of alternative splicing in orthologous genes from the human and mouse genomes was analyzed. Alternatively spliced mouse genes from the AsMamDB database were used to scan the draft human genome. The mouse protein isoforms were aligned with respect to orthologous human genes, and thus the exon-intron structure of the latter was established. Proteins isoforms that could not be aligned throughout their length were analyzed in detail using the human EST alignment.

Original languageEnglish
Number of pages1
JournalBiofizika
Volume47
Issue number4
Publication statusPublished - 2002
Externally publishedYes

Keywords

  • Alternative splicing
  • Computer analysis
  • Exon-intron structure

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