Intracellularly degradable polyelectrolyte microcapsules

Bruno G. De Geest, Roosmarijn E. Vandenbroucke, Anja M. Guenther, Gleb B. Sukhorukov, Wim E. Hennink, Niek N. Sanders, Joseph Demeester, Stefaan C. De Smedt

Research output: Contribution to journalArticlepeer-review

288 Citations (Scopus)

Abstract

A method to design intracellularly degradable polyelectrolyte microcapsules, was investigated. Two types of degradable capsules were fabricated by using calcium carbonate (CaCO3) microparticles as a template. CaCO3 particles were prepared by a precipitation reaction between calcium chloride (CaCl2 and sodium carbonate (Na 2CO3 under vigorous stirring. Four centrifugation and washing steps with pure water were performed to remove the unreacted species. The particles were washed with acetone and then air-dried in the last step. The CaCO3 core material was removed by complexation with ethylenediaminetetraacetic acid (EDTA). The intracellularly degradable polyelectrolyte capsules produced by using the method could be attractive for the delivery of drugs with an intracellular target.

Original languageEnglish
Pages (from-to)1005-1009
Number of pages5
JournalAdvanced Materials
Volume18
Issue number8
DOIs
Publication statusPublished - 18 Apr 2006
Externally publishedYes

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