Intracellular Delivery of Antioxidant CeO2 Nanoparticles via Polyelectrolyte Microcapsules

Anton L. Popov, Nelli R. Popova, Nadezda V. Tarakina, Olga S. Ivanova, Artem M. Ermakov, Vladimir K. Ivanov, Gleb B. Sukhorukov

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)


Cerium oxide nanoparticles (nanoceria) are regarded as one of the most promising inorganic antioxidants for biomedical applications. Considering nanoceria as a potential therapeutic agent, we aimed to develop a robust system for its intracellular delivery using layer-by-layer polyelectrolyte microcapsules. We have shown that citrate-stabilized cerium oxide nanoparticles can be effectively incorporated into the structure of polyelectrolyte microcapsules made from biodegradable and nonbiodegradable polymers. The structure and morphology of synthesized microcapsules were investigated and analyzed using confocal laser scanning microscopy, scanning electron microscopy, transmission electron microscopy, energy-dispersive X-ray spectroscopy, and UV/vis spectroscopy. Results of experiments in vitro on B50 neuroblastoma cells confirmed nanoceria delivery into the cell while maintaining their antioxidant properties. The results presented confirm polyelectrolyte microcapsules to be an efficient intracellular delivery system for therapeutic nanoparticles.

Original languageEnglish
Pages (from-to)2453-2462
Number of pages10
JournalACS Biomaterials Science and Engineering
Issue number7
Publication statusPublished - 9 Jul 2018
Externally publishedYes


  • antioxidant activity
  • cell culture
  • cerium oxide nanoparticles
  • oxidative stress
  • polyelectrolyte microcapsules


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