Interaction of bacterial DNA-dependent RNA polymerase with promoters

K. V. Severinov

Research output: Contribution to journalArticlepeer-review


Transcription initiation is the most regulated step in the transcription cycle and directly affects the overall level of gene expression. Bacterial RNA polymerase (RNAP) requires a σ subunit to recognize the basal conserved promoter elements and melt DNA at the transcription start site. However, various domains and structural elements of the RNAP core enzyme directly contact promoter DNA in the promoter complex, suggesting that the σ subunit is not the only determinant of the recognition of promoter DNA and stability of the promoter complex formed by the RNAP holoenzyme. The review summarizes data on the role of the structural elements of the bacterial RNAP core enzyme in promoter recognition.

Original languageEnglish
Pages (from-to)376-386
Number of pages11
JournalMolecular Biology
Issue number3
Publication statusPublished - Jun 2007
Externally publishedYes


  • Promoter
  • RNA polymerase
  • Transcription initiation


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