Influence of water-soluble derivatives of [60]fullerene on catalytic activity of monoaminе oxidase B and their membranotropic properties

A. V. Smolina, R. A. Kotelnikova, D. A. Poletaeva, P. A. Troshin, E. A. Khakina, A. V. Zhilenkov, Yu V. Soldatova, V. N. Shtolko, V. V. Grigoriev, G. N. Bogdanov, A. I. Kotelnikov

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of two water-soluble derivatives of [60]fullerene (WS[60]FDs) on mitochondrial monoamine oxidase B (MAO-B) involved in oxidative deamination of biogenic amines has been investigated. The studied compounds were shown to be inhibitors of MAO-B. The inhibitory mechanism and the inhibition constants were determined. It was shown that WS[60]FDs I and II penetrate in lipid bilayer of membrane of phosphatidylcholine liposomes and localize in the regions of both polar head and fatty acid groups of phospholipids. The equilibrium constants of fluorescent dye—WS[60]FDs complexes were determined.

Original languageEnglish
Pages (from-to)784-789
Number of pages6
JournalRussian Chemical Bulletin
Volume65
Issue number3
DOIs
Publication statusPublished - 1 Mar 2016
Externally publishedYes

Keywords

  • antioxidant activity
  • fluorescent dyes
  • inhibitors of monoaminе oxidase B
  • membranotropic properties
  • water-soluble derivatives of fullerenes

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