Influence of the laser assisted fabricated 3D porous scaffolds from bioceramoplasts of micron and nano sizes on culture of MMSC

I. Shishkovsky, S. Volchkov

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

7 Citations (Scopus)

Abstract

The objective of the investigation was to test the biocompatibility of 3D porous biopolymer matrices (tissue-cellular scaffolds), made of biocompatible and bioresorbable polymers (polycarbonate, polyetheretherketone /PEEK/, polycaprolactone), including the materials with biocompatible oxide ceramics additive (TiO2, Al2O3, ZrO2 and hydroxyapatite) of micron and nano sizes, for tissue-engineering purposes. The porous samples were prepared via a layer-by-layer SLS method. The surface microstructures and their roughness were analyzed by the optical microscopy equipped with the cell analysis software. The cellular morphology, proliferative activity and adhesion of the polymeric and ceramopolymeric matrices were the subjects for comparison. The study showed that all the tested materials posessed biocompatible properties. The experimentally estimated cell duplication speed per day turned out to be maximal for polycarbonate (0.279 duplications per day) and for PEEK + Al2O3 = 3:1 group (0.30 dupl/day) against 0.387 dupl/day for the reference sample and 0.270 dupl/day for the group of cells placed close to the pure titanium samples.

Original languageEnglish
Title of host publicationFundamentals of Laser-Assisted Micro- and Nanotechnologies 2013
PublisherSPIE
ISBN (Print)9780819499929
DOIs
Publication statusPublished - 2013
Externally publishedYes
EventInternational Symposium on Fundamentals of Laser-Assisted Micro- and Nanotechnologies, FLAMN 2013 - St. Petersburg-Pushkin, Russian Federation
Duration: 24 Jun 201328 Jun 2013

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume9065
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X

Conference

ConferenceInternational Symposium on Fundamentals of Laser-Assisted Micro- and Nanotechnologies, FLAMN 2013
Country/TerritoryRussian Federation
CitySt. Petersburg-Pushkin
Period24/06/1328/06/13

Keywords

  • biocompatible polymer
  • drug delivery systems (DDS)
  • multipotent mesenchymal stem cells (MMSC)
  • nano and micron size's biooxide ceramics
  • polycaprolactone
  • polyetheretherketone
  • porous scaffolds
  • Selective Laser Sintering (SLS)

Fingerprint

Dive into the research topics of 'Influence of the laser assisted fabricated 3D porous scaffolds from bioceramoplasts of micron and nano sizes on culture of MMSC'. Together they form a unique fingerprint.

Cite this