Increase of functional diversity by alternative splicing

Evgenia V. Kriventseva, Ina Koch, Rolf Apweiler, Martin Vingron, Peer Bork, Mikhail S. Gelfand, Shamil Sunyaev

Research output: Contribution to journalReview articlepeer-review

179 Citations (Scopus)


A large-scale analysis of protein isoforms arising from alternative splicing shows that alternative splicing tends to insert or delete complete protein domains more frequently than expected by chance, whereas disruption of domains and other structural modules is less frequent. If domain regions are disrupted, the functional effect, as predicted from 3D structure, is frequently equivalent to removal of the entire domain. Also, short alternative splicing events within domains, which might preserve folded structure, target functional residues more frequently than expected. Thus, it seems that positive selection has had a major role in the evolution of alternative splicing.

Original languageEnglish
Pages (from-to)124-128
Number of pages5
JournalTrends in Genetics
Issue number3
Publication statusPublished - 1 Mar 2003
Externally publishedYes


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