Impact of Salmonella infection on host hormone metabolism revealed by metabolomics

L. Caetano M. Antunes, Ellen T. Arena, Alfredo Menendez, Jun Han, Rosana B.R. Ferreira, Michelle M.C. Buckner, Petra Lolić, Lufiani L. Madilao, Jörg Bohlmann, Christoph H. Borchers, B. Brett Finlay

Research output: Contribution to journalArticlepeer-review

59 Citations (Scopus)

Abstract

The interplay between pathogens and their hosts has been studied for decades using targeted approaches, such as the analysis of mutants and host immunological responses. Although much has been learned from such studies, they focus on individual pathways and fail to reveal the global effects of infection on the host. To alleviate this issue, high-throughput methods, such as transcriptomics and proteomics, have been used to study host-pathogen interactions. Recently, metabolomics was established as a new method to study changes in the biochemical composition of host tissues. We report a metabolomic study of Salmonella enterica serovar Typhimurium infection. Our results revealed that dozens of host metabolic pathways are affected by Salmonella in a murine infection model. In particular, multiple host hormone pathways are disrupted. Our results identify unappreciated effects of infection on host metabolism and shed light on mechanisms used by Salmonella to cause disease and by the host to counter infection.

Original languageEnglish
Pages (from-to)1759-1769
Number of pages11
JournalInfection and Immunity
Volume79
Issue number4
DOIs
Publication statusPublished - Apr 2011
Externally publishedYes

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