[Identification of transthyretin posttranslational modifications 1n human blood using mass-spectrometric methods]

I. A. Popov, N. L. Starodubtseva, M. I. Indeĭkina, Iu I. Kostiukevich, A. S. Kononikhin, M. I. Nikolaeva, E. N. Kukaev, S. A. Kozin, A. A. Makarov, E. N. Nikolaev

Research output: Contribution to journalArticlepeer-review

Abstract

Transthyretin, one of the major plasma proteins, has a number of posttranslational modifications and mutations, some of which are associated with the development of severe diseases, for instance, familial amyloid neuropathy and Alzheimer's disease. In order to investigate the role of modified forms in the development of these diseases a complex analytical platform, based on two mass-spectrometric approaches (bottom-up and op-down) has been developed. The high efficiency of this method was shown using 10 plasma samples obtained from patients with Alzheimer's disease and healthy individuals.

Original languageEnglish
Pages (from-to)1011-1019
Number of pages9
JournalMolekulyarnaya Biologiya
Volume47
Issue number6
Publication statusPublished - 2013
Externally publishedYes

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