Identification of proteins of cardiovascular system in healthy subjects' urine during "dry" immersion

L. Kh Pastushkova, I. V. Dobrokhotov, O. M. Veselova, E. S. Tiys, A. S. Kononikhin, A. M. Novosiolova, M. Coupe, M. A. Custaud, I. M. Larina

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

We analyzed the urine proteome in 14 healthy volunteers who were subjected to 5-day dry immersion using proteomic analysis methods and bioinformatics approach. We identified nine proteins related to the cardiovascular system. It was shown that 5-day dry immersion modifies the urine proteomic profile, indicating renal, endocrine, circulatory, and metabolic changes. Most of these changes are characterized by both a very rapid development and very rapid restoration within return to normal conditions.

Original languageEnglish
Pages (from-to)330-339
Number of pages10
JournalHuman Physiology
Volume40
Issue number3
DOIs
Publication statusPublished - Jul 2014
Externally publishedYes

Keywords

  • cardiovascular system
  • chromatography-mass spectrometry
  • dry immersion
  • glomerular barrier
  • urinary protein profile

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