Identification of Horizontal Gene Transfer from Phylogenetic Gene Trees

V. V. V'yugin, M. S. Gelfand, V. A. Lyubetsky

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

We suggest a new procedure to search for the genes with horizontal transfer events in their evolutionary history. The search is based on analysis of topology difference between the phylogenetic trees of gene (protein) groups and the corresponding phylogenetic species trees. Numeric values are introduced to measure the discrepancy between the trees. This approach was applied to analyze 40 prokaryotic genomes classified into 132 classes of orthologs. This resulted in a list of the candidate genes for which the hypothesis of horizontal transfer in evolution looks true.

Original languageEnglish
Pages (from-to)571-584
Number of pages14
JournalMolecular Biology
Volume37
Issue number4
DOIs
Publication statusPublished - Jul 2003
Externally publishedYes

Keywords

  • Evolutionary event
  • Horizontal gene transfer
  • Phylogenetic protein tree
  • Phylogenetic species tree
  • Statistics of evolutionary event search
  • Tree reconciliation

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