Identification and characterization of a new family of C-type lectin-like genes from planaria Girardia tigrina

Dmitry A. Shagin, Ekaterina V. Barsova, Ekaterina A. Bogdanova, Olga V. Britanova, Nadia G. Gurskaya, Konstantin A. Lukyanov, Mikhail V. Matz, Natalia I. Punkova, Natalia Y. Usman, Eugene P. Kopantzev, Emili Salo, Sergey A. Lukyanov

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

A novel family of C-type lectin-like genes, denoted multi-domain free lectin (MDFL), was identified in the freshwater planaria Girardia (Dugesia) tigrina. We cloned several genes that encode proteins comprising a signal peptide and a number of consecutive C-type lectin-like domains (CTLDs) interconnected by short linker stretches. Analyses of genomic organization, CTLD amino acid sequences, and the overall architecture of these proteins indicate that planarian proteins are a separate family of C-type lectin-like proteins. These genes are expressed in specifically differentiated gland cells of planaria and the corresponding proteins are excreted as components of the planarian body surface mucus.

Original languageEnglish
Pages (from-to)463-472
Number of pages10
JournalGlycobiology
Volume12
Issue number8
DOIs
Publication statusPublished - Aug 2002
Externally publishedYes

Keywords

  • CTLD
  • Multidomain free lectin
  • Planarian
  • Planarian gland cells

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