Hypochlorite-Induced Damage of Plasminogen Molecules: Structural-Functional Disturbance

A. D. Vasilyeva, L. V. Yurina, A. N. Shchegolikhin, A. E. Bugrova, T. S. Konstantinova, M. I. Indeykina, A. S. Kononikhin, E. N. Nikolaev, M. A. Rosenfeld

    Research output: Contribution to journalArticlepeer-review

    2 Citations (Scopus)

    Abstract

    Abstract: Plasminogen, the precursor of plasmin, is a serine protease that plays a fundamental role in the intravascular thrombolysis. For the first time, by using high-resolution mass spectrometry, data on the oxidative modifications of the plasminogen molecule under induced oxidation were obtained. The FTIR data show that, under oxidation on the protein, its secondary structure also undergoes the rearrangements. The high tolerance of plasminogen to oxidation can be due to both the closed conformation and the ability of some Met residues to serve as ROS trap.

    Original languageEnglish
    Pages (from-to)332-337
    Number of pages6
    JournalDoklady Biochemistry and Biophysics
    Volume488
    Issue number1
    DOIs
    Publication statusPublished - 1 Sep 2019

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