Hybrid PCL/CaCO3 scaffolds with capabilities of carrying biologically active molecules: Synthesis, loading and in vivo applications

M. S. Saveleva, A. N. Ivanov, M. O. Kurtukova, V. S. Atkin, A. G. Ivanova, G. P. Lyubun, A. V. Martyukova, E. I. Cherevko, A. K. Sargsyan, A. S. Fedonnikov, I. A. Norkin, A. G. Skirtach, D. A. Gorin, B. V. Parakhonskiy

    Research output: Contribution to journalArticlepeer-review

    40 Citations (Scopus)

    Abstract

    Designing advanced biomaterials for tissue regeneration with drug delivery and release functionalities remains a challenge in regenerative medicine. In this research, we have developed novel composite scaffolds based on polymeric polycaprolactone fibers coated with porous calcium carbonate structures (PCL/CaCO3) for tissue engineering and have shown their drug delivery and release in rats. In vivo biocompatibility tests of PCL/CaCO3 scaffolds were complemented with in vivo drug release study, where tannic acid (TA) was used as a model drug. Release of TA from the scaffolds was realized by recrystallization of the porous vaterite phase of calcium carbonate into the crystalline calcite. Cell colonization and tissue vascularization as well as transplantability of developed PCL/CaCO3 + TA scaffolds were observed. Detailed study of scaffold transformations during 21-day implantation period was followed by scanning electron microscopy and X-ray diffraction studies before and after in vivo implantation. The presented results demonstrate that PCL/CaCO3 scaffolds are attractive candidates for implants in bone regeneration and tissue engineering with a possibility of loading biologically active molecules and controlled release.

    Original languageEnglish
    Pages (from-to)57-67
    Number of pages11
    JournalMaterials Science and Engineering C
    Volume85
    DOIs
    Publication statusPublished - 1 Apr 2018

    Keywords

    • Calcium carbonate
    • In vivo biocompatibility
    • Rat
    • Scaffold drug delivery
    • Tannic acid
    • Tissue regeneration

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