Human mineralocorticoid receptor genomic structure and identification of expressed isoforms

M. C. Zennaro, M. C. Keightley, Y. Kotelevtsev, G. S. Conway, F. Soubrier, P. J. Fuller

Research output: Contribution to journalArticlepeer-review

110 Citations (Scopus)

Abstract

Most of the known effects of aldosterone are mediated by the mineralocorticoid receptor, an intracellular receptor belonging to the steroid/thyroid hormone/retinoic acid receptor superfamily. We determined the genomic structure of the human MR (hMR) and identified 10 exons in the gene, including two exons (1α and 1β) that encode different 5'-untranslated sequence. Expression of the two different hMR variants is under the control of two different promoters that contain no obvious TATA element, but multiple GC boxes. Our results indicate that hMR expression is regulated by alternative promoters perhaps in a tissue- or developmental-specific manner.

Original languageEnglish
Pages (from-to)21016-21020
Number of pages5
JournalJournal of Biological Chemistry
Volume270
Issue number36
DOIs
Publication statusPublished - 1995
Externally publishedYes

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