History of chromosome rearrangements reflects the spatial organization of yeast chromosomes

Ekaterina E. Khrameeva, Geoffrey Fudenberg, Mikhail S. Gelfand, Leonid A. Mirny

    Research output: Contribution to journalArticlepeer-review

    4 Citations (Scopus)

    Abstract

    Three-dimensional (3D) organization of genomes affects critical cellular processes such as transcription, replication, and deoxyribo nucleic acid (DNA) repair. While previous studies have investigated the natural role, the 3D organization plays in limiting a possible set of genomic rearrangements following DNA repair, the influence of specific organizational principles on this process, particularly over longer evolutionary time scales, remains relatively unexplored. In budding yeast S.cerevisiae, chromosomes are organized into a Rabl-like configuration, with clustered centromeres and telomeres tethered to the nuclear periphery. Hi-C data for S.cerevisiae show that a consequence of this Rabl-like organization is that regions equally distant from centromeres are more frequently in contact with each other, between arms of both the same and different chromosomes. Here, we detect rearrangement events in Saccharomyces species using an automatic approach, and observe increased rearrangement frequency between regions with higher contact frequencies. Together, our results underscore how specific principles of 3D chromosomal organization can influence evolutionary events.

    Original languageEnglish
    Article number1641002
    JournalJournal of Bioinformatics and Computational Biology
    Volume14
    Issue number2
    DOIs
    Publication statusPublished - 1 Apr 2016

    Keywords

    • chromatin
    • chromosomes
    • Hi-C
    • Rearrangements
    • Saccharomyces cerevisiae
    • translocations
    • yeasts

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