High throughput screening platform for new inhibitors of protein biosynthesis

P. V. Sergiev, I. A. Osterman, A. Ya Golovina, E. S. Andreyanova, I. G. Laptev, F. I. Pletnev, S. A. Evfratov, E. I. Marusich, M. S. Veselov, S. V. Leonov, Ya A. Ivanenkov, A. A. Bogdanov, O. A. Dontsova

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

The search for new antibiotics is an important task, which is of interest for both basic research and health care practices. It is essential to elucidate the mechanism of antimicrobial action during the screening for antimicrobial activity and at the same time be able to test thousands of compounds. A robotic screening system for potential antibiotics developed at the Department of Chemistry at Moscow State University has been described that enables the immediate identification of those that inhibit protein biosynthesis.

Original languageEnglish
Pages (from-to)65-67
Number of pages3
JournalMoscow University Chemistry Bulletin
Volume71
Issue number1
DOIs
Publication statusPublished - 1 Jan 2016
Externally publishedYes

Keywords

  • antibiotic
  • bacterium
  • protein synthesis
  • reporter strain
  • screening

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