Gold nanoparticle-carbon nanotube multilayers on silica microspheres: Optoacoustic-Raman enhancement and potential biomedical applications

Daniil Nozdriukhin, Nadezhda Besedina, Vasiliy Chernyshev, Olga Efimova, Polina Rudakovskaya, Marina Novoselova, Daniil Bratashov, Roman Chuprov-Netochin, Roman Kamyshinsky, Alexander Vasiliev, Dmitry Chermoshentsev, Sergey A. Dyakov, Vladimir Zharov, Nikolay Gippius, Dmitry A. Gorin, Alexey Yashchenok

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

There has been growing interest in recent years in developing multifunctional materials for studying the structure interface in biological systems. In this regard, the multimodal systems, which possess activity in the near-infrared (NIR) region, become even more critical for the possibility of improving examined biotissue depth and, eventually, data analysis. Herein, we engineered bi-modal contrast agents by integrating carbon nanotubes (CNT) and gold nanoparticles (AuNP) around silica microspheres using the Layer-by-Layer self-assembly method. The experimental studies revealed that microspheres with CNT sandwiched between AuNP exhibit strong absorption in the visible and NIR regions and high optoacoustic contrast (OA, also called photoacoustics) and Raman scattering when illuminated with 532 nm and 785 nm lasers, respectively. The developed microspheres demonstrated amplification of the signal in the OA flow cytometry at the laser wavelength of 1064 nm. This finding was further validated with ex vivo brain tissue using a portable Raman spectrometer and imaging with the Raster-scanning OA mesoscopy technique. The obtained data suggest that the developed contrast agents can be promising in applications of localization OA tomography (LOT), OA flow cytometry, and multiplex SERS detection.

Original languageEnglish
Article number111736
JournalMaterials Science and Engineering C
Volume120
DOIs
Publication statusPublished - Jan 2021

Keywords

  • Bimodal contrast agents
  • Brain imaging
  • Carbon nanotubes
  • Gold nanoparticles
  • Optoacoustic flow cytometry
  • Raster-scanning optoacoustic mesoscopy
  • SERS

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