Global transcriptional response of Nitrosomonas europaea to chloroform and chloromethane

Barbara O. Gvakharia, Elizabeth A. Permina, Mikhail S. Gelfand, Peter J. Bottomley, Luis A. Sayavedra-Soto, Daniel J. Arp

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)

Abstract

Upon exposure of Nitrosomonas europaea to chloroform (7 μM, 1 h), transcripts for 175 of 2,460 genes were found at higher levels in treated cells than in untreated cells and transcripts for 501 genes were found at lower levels. With chloromethane (3.2 mM, 1 h), transcripts for 67 genes were at higher levels and transcripts for 148 genes were at lower levels. Transcripts for 37 genes were at higher levels following both treatments and included genes for heat shock proteins, σ-factors of the extracytoplasmic function subfamily, and toxin-antitoxin loci. N. europaea has higher levels of transcripts for a variety of defense genes when exposed to chloroform or chloromethane.

Original languageEnglish
Pages (from-to)3440-3445
Number of pages6
JournalApplied and Environmental Microbiology
Volume73
Issue number10
DOIs
Publication statusPublished - May 2007
Externally publishedYes

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