Genetic determinants of diastolic and pulse pressure map to different loci in Lyon hypertensive rats

Christopher Dubay, Madeleine Vincent, Nilesh J. Samani, Pascale Hilbert, Michael A. Kaiser, Jean Paul Beressi, Yuri Kotelevtsev, Jacques S. Beckmann, Florent Soubrier, Jean Sassard, G. Mark Lathrop

Research output: Contribution to journalArticlepeer-review

126 Citations (Scopus)

Abstract

Several genetic loci involved in blood pressure regulation have recently been localized in experimental models of hypertension, but the manner in which they influence blood pressure remains unknown. Here, we report a study of the Lyon hypertensive rat strain showing that different loci are involved in the regulation of steady-state (diastolic pressure) and pulsatile (systolic – diastolic, or pulse pressure) components of blood pressure. Significant linkage was established between diastolic blood pressure and a microsatellite marker of the renin gene (REN) on rat chromosome 13, and between pulse pressure and the carboxypeptidase B gene (CPB) on chromosome 2. These findings show that two independent loci influence different haemodynamic components of blood pressure, and that pulse pressure has a specific genetic determination.

Original languageEnglish
Pages (from-to)354-357
Number of pages4
JournalNature Genetics
Volume3
Issue number4
DOIs
Publication statusPublished - Apr 1993
Externally publishedYes

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