Objective. To elaborate an analytical approach to predicting fetal macrosomia (FM) on the basis of maternal serum lipidome analysis. Subjects and methods. A prospective cohort study enrolled 120 pregnant women with FM and gestational diabetes mellitus (GDM). Serum lipid levels were analyzed by mass spectrometry. Results. The best prognostic models were obtained at 11-14 and 24-28 weeks’ gestation in women with GDM (the sensitivity and specificity were 0.91/0.96 and 0.93/0.96, respectively), at 11-14 weeks in the entire group and in patients without GDM (0.85/0.91 and 0.93/0.92). The findings make it possible to predict FM according to the presence or absence of GDM. Conclusion. The introduction of the developed models into obstetric practice will become a new tool for assessing the risk for FM, which will be able to reduce its rate and to improve maternal and perinatal outcomes.
- Fetal macrosomia
- Gestational diabetes mellitus
- Mass spectrometry