Evolutionary patterns of phosphorylated serines

Yerbol Z. Kurmangaliyev, Alexander Goland, Mikhail S. Gelfand

Research output: Contribution to journalComment/debate

7 Citations (Scopus)

Abstract

Posttranslationally modified amino acids are chemically distinct types of amino acids and in terms of evolution they might behave differently from their non-modified counterparts. In order to check this possibility, we reconstructed the evolutionary history of phosphorylated serines in several groups of organisms. Comparisons of substitution vectors have revealed some significant differences in the evolution of modified and corresponding non-modified amino acids. In particular, phosphoserines are more frequently substituted to aspartate and glutamate, compared to non-phosphorylated serines.Reviewers: This article was reviewed by Arcady Mushegian and Sandor Pongor.

Original languageEnglish
Article number8
JournalBiology Direct
Volume6
DOIs
Publication statusPublished - 9 Feb 2011
Externally publishedYes

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