Evolutionary differences between alternative and constitutive protein-coding regions of alternatively spliced genes of Drosophila

E. O. Ermakova, D. B. Mal'ko, M. S. Gelfand

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

A total of 790 Drosophila melanogaster genes that are alternatively spliced in a coding region and have orthologs in Drosophila pseudoobscura were studied. It proved that nucleotide substitutions are accumulated in alternative coding regions more rapidly than in constitutive coding regions. Moreover, the evolutionary patterns of alternative regions differing in insertion-deletion mechanisms (use of alternative promoters, splicing sites, or polyadenylation sites) differ significantly. The synonymous substitution rate in coding regions of genes varies more strongly than the nonsynonymous substitution rate. The patterns of substitutions in different classes of alternative regions of Drosophila melanogaster and mammals differ considerably.

Original languageEnglish
Pages (from-to)515-522
Number of pages8
JournalBiophysics (Russian Federation)
Volume51
Issue number4
DOIs
Publication statusPublished - Aug 2006
Externally publishedYes

Keywords

  • Alternative splicing
  • Drosophila
  • Molecular evolution
  • Nucleotide substitutions

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