Evolution of the NadR regulon in enterobacteriaceae

Anna V. Gerasimova, Mikhail S. Gelfand

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


The NAD biosynthetic pathway and NAD transformations in E. coli and S. typhi are well characterized. Using comparative genomics methods we describe the NadR regulon in other Enterobacteriaceae, identity new candidate regulon members and demonstrate that even a very simple regulon covering an essential methabolic pathway could be different in closely related genomes.

Original languageEnglish
Pages (from-to)1007-1019
Number of pages13
JournalJournal of Bioinformatics and Computational Biology
Issue number4
Publication statusPublished - Aug 2005
Externally publishedYes


  • Comparative genomics
  • Evolution
  • NAD biosynthesis
  • NadR
  • Phylogenetic footprinting
  • Regulation of transcription
  • Transcription factor


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