Evaluating the number of mitochondrial DNA copies in leukocytes and adipocytes from metabolic syndrome patients: Pilot study

O. I. Mozhey, P. A. Zatolokin, M. A. Vasilenko, L. S. Litvinova, E. V. Kirienkova, I. O. Mazunin

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Metabolic syndrome is a complex of metabolic, hormonal, and clinical disorders. Defects in mitochondrial functions play an important role in the metabolic syndrome pathogenesis. Here, variations in the number of mitochondrial DNA (mtDNA) copies were evaluated in different fat-tissue and peripheral-blood-leukocyte samples from metabolic syndrome patients ranked by body mass indices. The number of mtDNA copies showed a tendency to decrease with increase body mass index.

Original languageEnglish
Pages (from-to)590-593
Number of pages4
JournalMolecular Biology
Volume48
Issue number4
DOIs
Publication statusPublished - Jul 2014
Externally publishedYes

Keywords

  • adipocytes
  • body mass index
  • metabolic syndrome
  • mitochondrial DNA number of copies

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