Enzyme reaction in the pores of CaCO3 particles upon ultrasound disruption of attached substrate-filled liposomes

Alexey M. Yashchenok, Mihaela Delcea, Kristina Videnova, Elizabeth A. Jares-Erijman, Thomas M. Jovin, Manfred Konrad, Helmuth Möhwald, Andre G. Skirtach

Research output: Contribution to journalArticlepeer-review

68 Citations (Scopus)

Abstract

Breaking out: Liposomes that are adsorbed onto porous CaCO3 particles and that contain the peroxidase substrate Amplex Red (AR) are disrupted by ultrasonic treatment. The substrate is released and diffuses into the inner part of the multicompartment containers where the peroxidase enzyme is found, and the enzymatic reaction is triggered. This approach may be useful for the simultaneous delivery of multiple molecules into cells.

Original languageEnglish
Pages (from-to)8116-8120
Number of pages5
JournalAngewandte Chemie - International Edition
Volume49
Issue number44
DOIs
Publication statusPublished - 25 Oct 2010
Externally publishedYes

Keywords

  • Drug delivery
  • Enzyme reactions
  • Microparticles
  • Nanocontainers
  • Ultrasound

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