Entrapment of herbal extraxts in biodegradable microcapsules

T. N. Borodina, L. D. Rumsh, S. M. Kunizhev, G. B. Sukhorukov, G. N. Vorozhtsov, B. M. Feldman, A. V. Rusanova, T. V. Vasil'eva, S. M. Strukova, E. A. Markvicheva

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

The microcapsules with entrapped herbal water-soluble extracts Plantago major and Calendula officinalis L. (HE) were prepared by LbL-adsorption of carrageenan and modificated chitosan onto CaCO3 microparticles with their subsequent dissolving after the treatment of EDTA. Entrapment of HE was performed by adsorption and co-precipitation techniques. The co-precipitation provided better entrapment of HE compared to adsorption. In vitro release kinetics in an artificial gastric juice (AGJ) was studied. The HE release was shown to accelerate gastric ulcer treatment in a rat model.

Original languageEnglish
Pages (from-to)662-671
Number of pages10
JournalBiomeditsinskaya Khimiya
Volume53
Issue number6
Publication statusPublished - 2007
Externally publishedYes

Keywords

  • Biodegradation
  • Carrageenan
  • Herbal extracts
  • Microcapsules
  • Modificated chitosan
  • Pepsin
  • Sustained drug release

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