Effect of fullerenes C60 on X-protein amyloids

L. G. Marsagishvili, A. G. Bobylev, M. D. Shpagina, P. A. Troshin, Z. A. Podlubnaya

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

The inhibitory effect of hydrated fullerene C60 and the sodium salt of the fullerene polycarboxylic derivative C60Cl(C6H4CH2COONa)5 on the formation of amyloid fibrils by X-protein in vitro has been studied by electron microscopy. It is shown that these compounds not only destroy mature amyloid fibrils but also prevent the formation of new fibrils. This property of fullerenes, which are nanoparticles, can be used to develop a novel medical nanotechnology in the therapy for amyloidoses.

Original languageEnglish
Pages (from-to)135-138
Number of pages4
JournalBiophysics (Russian Federation)
Volume54
Issue number2
DOIs
Publication statusPublished - 2009
Externally publishedYes

Keywords

  • Amyloids
  • Fullerene polycarboxylic derivative
  • Skeletal muscle
  • X-protein

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