Effect of fullerenes C60 on X-protein amyloids

L. G. Marsagishvili, A. G. Bobylev, M. D. Shpagina, P. A. Troshin, Z. A. Podlubnaya

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


The inhibitory effect of hydrated fullerene C60 and the sodium salt of the fullerene polycarboxylic derivative C60Cl(C6H4CH2COONa)5 on the formation of amyloid fibrils by X-protein in vitro has been studied by electron microscopy. It is shown that these compounds not only destroy mature amyloid fibrils but also prevent the formation of new fibrils. This property of fullerenes, which are nanoparticles, can be used to develop a novel medical nanotechnology in the therapy for amyloidoses.

Original languageEnglish
Pages (from-to)135-138
Number of pages4
JournalBiophysics (Russian Federation)
Issue number2
Publication statusPublished - 2009
Externally publishedYes


  • Amyloids
  • Fullerene polycarboxylic derivative
  • Skeletal muscle
  • X-protein


Dive into the research topics of 'Effect of fullerenes C60 on X-protein amyloids'. Together they form a unique fingerprint.

Cite this