Downregulation of the Arg/N-degron Pathway Sensitizes Cancer Cells to Chemotherapy In Vivo

Dominique Leboeuf, Tatiana Abakumova, Tatiana Prikazchikova, Luke Rhym, Daniel G. Anderson, Timofei S. Zatsepin, Konstantin I. Piatkov

    Research output: Contribution to journalArticlepeer-review

    11 Citations (Scopus)

    Abstract

    With the use of a small interfering RNA (siRNA)-mediated approach for selective downregulation of the Arg/N-degron pathway in a murine hepatocellular carcinoma model, Leboeuf et al. demonstrated potentiated action of chemotherapy. Since components of this pathway are ubiquitously expressed, targeting the N-degron pathway has the potential to increase effectiveness of therapy in many cancer types.

    Original languageEnglish
    Pages (from-to)1092-1104
    Number of pages13
    JournalMolecular Therapy
    Volume28
    Issue number4
    DOIs
    Publication statusPublished - 8 Apr 2020

    Keywords

    • apoptosis
    • chemotherapy
    • hepatocellular carcinoma
    • N-degron pathway
    • UBR-ubiquitin ligases
    • UBR1
    • UBR2
    • UBR4
    • UBR5

    Fingerprint

    Dive into the research topics of 'Downregulation of the Arg/N-degron Pathway Sensitizes Cancer Cells to Chemotherapy In Vivo'. Together they form a unique fingerprint.

    Cite this