Does a deficiency of the signal recognition particle (SRP)-pathway affect the biosynthesis of its components in Saccharomyces cerevisiae and Escherichia coli?

O. N. Kovalskaya, P. V. Sergiev, A. A. Bogdanov, O. A. Dontsova

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

We studied the behavior of the signal recognition particle (SRP) components in Saccharomyces cerevisiae upon deficiencies of the protein transport caused by the absence of the SRP membrane receptor α-subunit. A decrease in the concentration of the SRP membrane receptor α-subunit in the cell significantly decreased the level of an SRP component, protein SRP72, as well as the levels of mRNAs of SRP protein components and the SRP receptor β-subunit. But the amount of 7SL RNA remained unchanged. In contrast, in Escherichia coli cells the gradual decrease in the level of the protein FtsY (a homolog of the SRP membrane receptor α-subunit) was not associated with changes in the Ffh protein level.

Original languageEnglish
Pages (from-to)723-729
Number of pages7
JournalBiochemistry (Moscow)
Volume71
Issue number7
DOIs
Publication statusPublished - Jul 2006
Externally publishedYes

Keywords

  • Cotranslational protein transport
  • Signal recognition particle (SRP)
  • Transcription regulation

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