Direct arylation of C60Cl6 and C70Cl8 with carboxylic acids: A synthetic avenue to water-soluble fullerene derivatives with promising antiviral activity

Olga A. Kraevaya, Alexander S. Peregudov, Ivan A. Godovikov, Elena V. Shchurik, Vyacheslav M. Martynenko, Alexander F. Shestakov, Jan Balzarini, Dominique Schols, Pavel A. Troshin

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

We report unprecedented Friedel-Crafts arylation of chlorofullerenes C60Cl6 and C70Cl8 with unprotected carboxylic acids as an efficient single-step synthesis of the inherently stable water-soluble fullerene derivatives. Using this method, a series of previously unaccessible compounds was obtained without chromatographic purification in almost quantitative yields. Promising anti-HIV activity comparable to characteristics of commercial drugs was demonstrated for some of these compounds.

Original languageEnglish
Pages (from-to)1179-1182
Number of pages4
JournalChemical Communications
Volume56
Issue number8
DOIs
Publication statusPublished - 2020

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