Detection of planarian Antennapedia-like homeobox genes expressed during regeneration

V. S. Tarabykin, K. A. Lukyanov, V. K. Potapov, S. A. Lukyanov

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

Using the polymerase chain reaction with degenerate oligo primers we identified six new Antennapedia-like homeobox sequences expressed in a regenerating planarian. cDNA fragments containing the entire homeobox sequences for four of these genes were obtained. Two of them, Dutarh-3 and Dutarh-4, belong to the classical Antennapedia type and display extensive identity with Antennapedia- and Deformed-type homeodomains respectively. The third homeodomain, Dutarh-1, exhibits some similarity to the Hox1.5-, AbdB- and Dfd-type homeodomains and a fourth gene, Dutarh-6, is very similar to Mox2 in the mouse. Oar results suggest that, in spite of their simple body plan, planarians contain a number of Antennapedia-like homeobox genes, probably enough to fill a cluster such as found in higher animals.

Original languageEnglish
Pages (from-to)197-202
Number of pages6
JournalGene
Volume158
Issue number2
DOIs
Publication statusPublished - 9 Jun 1995
Externally publishedYes

Keywords

  • Drosophila
  • Homeodomain
  • mouse
  • polymerase chain reaction
  • primer

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