Defined picogram dose inclusion and release of macromolecules using polyelectrolyte microcapsules

Christophe Déjugnat, David Haložan, Gleb B. Sukhorukov

Research output: Contribution to journalArticlepeer-review

70 Citations (Scopus)

Abstract

Reversible pH-induced swelling of (PAH/PSS) polyelectrolyte microcapsules is accompanied by increased porosity, making them permeable to poly(acrylic acid) (PAA) at pH values higher than 11.2. This pH-switchable permeability was used to encapsulate the polyanion in alkaline conditions. Relationship between starting PAA concentration in solution and amount finally being encapsulated has been established and can be used further as calibration curve. A desired amount of encapsulated polymer in the picogram range per capsule can be achieved. The loaded capsules were then used as microreactors by forming a complex between the PAA and Ca2+ ions.

Original languageEnglish
Pages (from-to)961-967
Number of pages7
JournalMacromolecular Rapid Communications
Volume26
Issue number12
DOIs
Publication statusPublished - 16 Jun 2005
Externally publishedYes

Keywords

  • Encapsulation
  • Layer-by-layer
  • Microreactor
  • pH sensitivity
  • Stimuli-responsive

Fingerprint

Dive into the research topics of 'Defined picogram dose inclusion and release of macromolecules using polyelectrolyte microcapsules'. Together they form a unique fingerprint.

Cite this