Damage-repair error-prone polymerases of eubacteria: Association with mobile genome elements

Elizaveta A. Permina, Andrey A. Mironov, Mikhail S. Gelfand

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)

Abstract

It is known that umuDC-like operons encoding DNA polymerase V are often found in plasmids of gamma-proteobacteria. Here we demonstrate that homologous operons are associated with mobile genomic elements in Gram-positive bacteria as well. Using the comparative analysis of transcriptional regulatory signals, we suggest that genes encoding homologs of UmuC in prophages of Bacillus subtilis and transposons of Enterococus faecalis are regulated by DinR (SOS repressor). We also predict a functional link between the polymerase V-like proteins of B. subtilis and the protein family containing YolD, YozL and YqjX.

Original languageEnglish
Pages (from-to)133-140
Number of pages8
JournalGene
Volume293
Issue number1-2
DOIs
Publication statusPublished - 26 Jun 2002
Externally publishedYes

Keywords

  • Computational analysis
  • Error-prone DNA polymerase
  • Prophage
  • SOS response
  • Transposone

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