Cytotoxicity of nanoparticle-loaded polymer capsules

C. Kirchner, A. Muñoz Javier, A. S. Susha, A. L. Rogach, O. Kreft, G. B. Sukhorukov, W. J. Parak

Research output: Contribution to journalArticlepeer-review

110 Citations (Scopus)

Abstract

Cytotoxic effects of micrometer-sized polymer capsules composed out of alternating layers of polystyrenesulfonate (PSS) and polyallylamine hydrochloride (PAH) on a fibroblast cell line have been investigated with an adhesion assay. For the purpose of visualization with fluorescence nanometer-sized CdTe nanoparticles have been embedded in the walls of the capsules. Similar to free CdTe nanoparticles, toxic Cd-ions are also released from CdTe nanoparticles that have been embedded in capsules. At high capsule concentrations, the capsules start to sediment on top of the cells and thus impair cell viability.

Original languageEnglish
Pages (from-to)486-491
Number of pages6
JournalTalanta
Volume67
Issue number3
DOIs
Publication statusPublished - 15 Sep 2005
Externally publishedYes

Keywords

  • Cytotoxicity
  • Nanoparticle
  • Polymer capsule

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