Crystal Structure of the Human Cannabinoid Receptor CB2

Xiaoting Li, Tian Hua, Kiran Vemuri, Jo Hao Ho, Yiran Wu, Lijie Wu, Petr Popov, Othman Benchama, Nikolai Zvonok, K'ara Locke, Lu Qu, Gye Won Han, Malliga R. Iyer, Resat Cinar, Nathan J. Coffey, Jingjing Wang, Meng Wu, Vsevolod Katritch, Suwen Zhao, George KunosLaura M. Bohn, Alexandros Makriyannis, Raymond C. Stevens, Zhi Jie Liu

Research output: Contribution to journalArticlepeer-review

181 Citations (Scopus)

Abstract

The structure of the human cannabinoid receptor CB2 reveals how small molecules affect CB2 differently than CB1 and point to principles that could inform rational and selective drug design.

Original languageEnglish
Pages (from-to)459-467.e13
JournalCell
Volume176
Issue number3
DOIs
Publication statusPublished - 24 Jan 2019
Externally publishedYes

Keywords

  • cannabinoid receptor CB2
  • crystal structure
  • G-protein coupled receptor
  • ligand design
  • subtype selectivity

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