CRISPR adaptive immunity systems of prokaryotes

K. S. Pougach, A. V. Lopatina, K. V. Severinov

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)


CRISPR (clustered regularly interspaced short palindromic repeats) systems were found in the genomes of many eubacteria and the vast majority of archaea. Their unique feature is that CRISPR-mediated immunity is adaptive and can be programmed to protect cells against mobile genetic elements. The review describes the general principles of CRISPR-mediated immunity and characterizes the CRISPR systems of various microorganisms.

Original languageEnglish
Pages (from-to)175-182
Number of pages8
JournalMolecular Biology
Issue number2
Publication statusPublished - Apr 2012
Externally publishedYes


  • adaptive immunity
  • Cas proteins
  • CRISPR systems
  • small RNAs


Dive into the research topics of 'CRISPR adaptive immunity systems of prokaryotes'. Together they form a unique fingerprint.

Cite this