CRISPR adaptive immunity systems of prokaryotes

K. S. Pougach, A. V. Lopatina, K. V. Severinov

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)

Abstract

CRISPR (clustered regularly interspaced short palindromic repeats) systems were found in the genomes of many eubacteria and the vast majority of archaea. Their unique feature is that CRISPR-mediated immunity is adaptive and can be programmed to protect cells against mobile genetic elements. The review describes the general principles of CRISPR-mediated immunity and characterizes the CRISPR systems of various microorganisms.

Original languageEnglish
Pages (from-to)175-182
Number of pages8
JournalMolecular Biology
Volume46
Issue number2
DOIs
Publication statusPublished - Apr 2012
Externally publishedYes

Keywords

  • adaptive immunity
  • Cas proteins
  • CRISPR systems
  • small RNAs

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