Computer analysis of the GCN4 regulon of yeast Saccharomyces cerevisiae

G. Yu Kovaleva, V. Yu Makeev, M. S. Gelfand

Research output: Contribution to journalArticlepeer-review


Binding sites of eukaryotic transcriptional regulators are often very short, and the specificity of recognition is attained by cooperative binding of regulators to clusters of sites. We analyzed clustering of binding sites of the global regulator of amino acid metabolism Gcn4p in regulatory regions of nine genes of yeast Saccharomyces cerevisiae and of orthologous genes of a phylogenetically quite distant yeast Candida albicans. Despite differences in the parameters characterizing the clusters, the clustering of candidate Gcn4p is retained in most regulatory regions, which confirms the functional significance of this phenomenon. Analysis of a control set of genes that are not regulated by Gcn4p demonstrates that this clustering is not random.

Original languageEnglish
Pages (from-to)S26-S29
JournalBiophysics (Russian Federation)
Issue numberSUPPL1
Publication statusPublished - 2003
Externally publishedYes


  • Clustering
  • Gcn4p binding sites
  • Transcriptional regulators
  • Yeast


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