Computer analysis of regulatory signals in complete bacterial genomes. LexA and DinR binding sites

M. S. Gelfand, A. A. Mironov

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

The method for recognition of transcription regulatory patterns using a combination of statistical analysis of operators and homology analysis of regulated genes was applied to the SOS regulons of Escherichia coli, Haemophilus influenzae, and Bacillus subtilis. New members of these regulons were found. It is demonstrated that recognition of the Cheo boxes by the regulatory protein DinR in B. subtilis is often cooperative and the mutual positioning of the operators is consistent with the geometry of the double helix.

Original languageEnglish
Pages (from-to)680-686
Number of pages7
JournalMolecular Biology
Volume33
Issue number5
Publication statusPublished - Sep 1999
Externally publishedYes

Keywords

  • Bacillus subtilis
  • Complete genomes
  • Computer analysis
  • DinR
  • Escherichia coli
  • Functional sites
  • Haemophilus influenzae
  • LexA
  • SOS operator

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