Computer analysis of control signals in bacterial genomes. Attenuators of operons of aromatic amino acids metabolism

A. G. Vitreshchak, M. S. Gel'fand

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Here we predict attenuators in operons of aromatic amino acids metabolism in the γ-subclass of proteobacteria Salmonella typhi, Yersinia pestis, Vibrio cholerae, Haemophilus influenzae, Actinobacillus actinomycetemcomitans, Xanthomonas campestris, and chlamydia Chlamydia trachomatis. Alternative secondary structures of mRNA governing transcription pathway selection as well as the related control leader peptide were constructed. Comparison with homologous Escherichia coli operons was used for the prediction. This control mechanism takes place in operons trp (tryptophan), phe (phenylalanine), and pheST coding for the large and small subunits of phenylalanine tRNA synthase in the considered γ-proteobacteria. Secondary structures of mRNA in the leader region of tnaAB operon possibly involved in ρ-dependent attenuation were predicted in certain enterobacteria.

Original languageEnglish
Pages (from-to)461-467
Number of pages7
JournalMolecular Biology
Volume34
Issue number4
DOIs
Publication statusPublished - 2000
Externally publishedYes

Keywords

  • Aromatic amino acid metabolism
  • Attenuation of transcription
  • Computer analysis
  • Functional signals
  • Gene expression control
  • Tnaab operon

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