Comparative genomics and evolution of alternative splicing: The Pessimists' Sciene

Irena I. Artamonova, Mikhail S. Gelfand

Research output: Contribution to journalReview articlepeer-review

38 Citations (Scopus)


Alternative splicing appears to be sciences' pessimist as nothing can reliably be identified along with its many other fundamental problems. On the brighter side, an optimism can still be seen as the splicing's noise provides material for selection of new and beneficial variants. The evolution of alternative splicing may allow various stages be fixed in different species. Specifically, the prevalence and function of alternative splicing is discussed. In addition, several other topics discussed include the evolution of exon-intron structure, the evolution of the alternative exon-intron structure and the functionality of nonconserved isoforms, the origin of alternative regions, the changes in alternative splicing after gene duplication, and lastly, the recognition of alternative exons and databases of alternative splicing.

Original languageEnglish
Pages (from-to)3407-3430
Number of pages24
JournalChemical Reviews
Issue number8
Publication statusPublished - Aug 2007
Externally publishedYes

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