Comparative analysis of FUR regulons in gamma-proteobacteria

E. M. Panina, A. A. Mironov, M. S. Gelfand

Research output: Contribution to journalArticlepeer-review

81 Citations (Scopus)


Iron is an essential element for the survival and pathogenesis of bacteria. The strict control of iron homeostasis is mediated by the FUR repressor, which is highly conserved among various bacterial species. Here we apply the comparative genomics approach to analyze candidate Fur-binding sites in the genomes of Escherichia coli (K12 and O157:H7), Salmonella typhi, Yersinia pestis and Vibrio cholerae. We describe a number of new loci encoding siderophore biosynthesis and transport proteins. A new regulator of iron-acquisition systems was found in S.typhi. We predict FUR regulation for several virulence systems. We also predict FUR regulation for the chemotaxis system of V.cholerae that is probably involved in the process of pathogenesis.

Original languageEnglish
Pages (from-to)5195-5206
Number of pages12
JournalNucleic Acids Research
Issue number24
Publication statusPublished - 24 Dec 2001
Externally publishedYes


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