Changes of protein profile of human urine after long-term orbital flights

L. Kh Pastushkova, O. A. Valeeva, A. S. Kononikhin, E. N. Nikolaev, I. M. Larina, I. V. Dobrokhotov, I. A. Popov, V. I. Pochuev, K. S. Kireev

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


We analyzed protein profile of urine samples obtained from 7 Russian cosmonauts (age 35-51 years), participants of space flights on the International Space Station lasting for 169-199 days. Gradient chromatography with linear increase of eluent proportion was carried out in a system consisting of an Agilent 1100 chromatograph (Agilent Technologies Inc.) and a hybrid mass-spectrometer LTQ-FT Ultra (Thermo). The obtained results help to understand changes in the human body induced by space flight factors.

Original languageEnglish
Pages (from-to)201-204
Number of pages4
JournalBulletin of Experimental Biology and Medicine
Issue number2
Publication statusPublished - Dec 2013
Externally publishedYes


  • International Space Station
  • mass-spectrometry
  • urine proteomics


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