Changes in the cerebral blood flow in newborn rats assessed by LSCI and DOCT before and after the hemorrhagic stroke

O. V. Semyachkina-Glushkovskaya, V. V. Lychagov, A. S. Abdurashitov, O. V. Sindeeva, S. S. Sindeev, E. M. Zinchenko, E. I. Kajbeleva, A. N. Pavlov, M. Kassim, V. V. Tuchin

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

3 Citations (Scopus)

Abstract

The incidence of perinatal hemorrhagic stroke (HS) is very similar to that in the elderly and produces a significant morbidity and long-term neurologic and cognitive deficits. There is strong evidence that cerebral blood flow (CBF) abnormalities make considerable contribution to HS development. However, the mechanisms responsible for pathological changes in CBF in infants with HS are not established. Therefore, quantitative assessment of CBF may significantly advance the understanding of the nature of neonatal stroke. The aim of this investigation was to determine the particularities of alterations in macro-microcirculation in the brain of newborn rats in the different stages of stress-related development of HS using three-dimensional Doppler optical coherence tomography (DOCT) and laser speckle contrast imaging (LSCI). Our results show that cerebral veins are more sensitive to harmful effect of stress compared with microcirculatory vessels. Stress-induced progressive dilation of cerebral veins with the fall of blood flow velocity precedes HS while pathological changes in microcirculatory vessels are accompanied by development of HS. The further detailed study of cerebral venous and microcirculatory circulation would be a significant advance in development of prognostic criteria for a HS risk during the first days after birthday.

Original languageEnglish
Title of host publicationOptical Techniques in Neurosurgery, Neurophotonics, and Optogenetics II
EditorsHenry Hirschberg, Steen J. Madsen, Qingming Luo, Samarendra K. Mohanty, Nitish V. Thakor, E. Duco Jansen
PublisherSPIE
ISBN (Electronic)9781628413953
DOIs
Publication statusPublished - 2015
Externally publishedYes
EventOptical Techniques in Neurosurgery, Neurophotonics, and Optogenetics II - San Francisco, United States
Duration: 7 Feb 201510 Feb 2015

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9305
ISSN (Print)1605-7422

Conference

ConferenceOptical Techniques in Neurosurgery, Neurophotonics, and Optogenetics II
Country/TerritoryUnited States
CitySan Francisco
Period7/02/1510/02/15

Keywords

  • cerebral microcirculation
  • Doppler optical coherence tomography
  • histopathological evaluation
  • laser speckle contrast imaging
  • neonatal stoke
  • rats

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