Changes in Lipidome Composition during Brain Development in Humans, Chimpanzees, and Macaque Monkeys

Qian Li, Katarzyna Bozek, Chuan Xu, Yanan Guo, Jing Sun, Svante Pääbo, Chet C. Sherwood, Patrick R. Hof, John J. Ely, Yan Li, Lothar Willmitzer, Patrick Giavalisco, Philipp Khaitovich

    Research output: Contribution to journalArticlepeer-review

    19 Citations (Scopus)

    Abstract

    Lipids are essential components of the brain. Here, we conducted a comprehensive mass spectrometry-based analysis of lipidome composition in the prefrontal cortex of 40 humans, 40 chimpanzees, and 40 rhesus monkeys over postnatal development and adulthood. Of the 11,772 quantified lipid peaks, 7,589 change significantly along the lifespan. More than 60% of these changes occur prior to adulthood, with less than a quarter associated with myelination progression. Evolutionarily, 36% of the age-dependent lipids exhibit concentration profiles distinct to one of the three species; 488 (18%) of them were unique to humans. In both humans and chimpanzees, the greatest extent of species-specific differences occurs in early development. Human-specific lipidome differences, however, persist over most of the lifespan and reach their peak from 20 to 35 years of age, when compared with chimpanzee-specific ones.

    Original languageEnglish
    Pages (from-to)1155-1166
    Number of pages12
    JournalMolecular Biology and Evolution
    Volume34
    Issue number5
    DOIs
    Publication statusPublished - 1 May 2017

    Keywords

    • Brain
    • Development
    • Evolution
    • Lipidome

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