Chain length is the main determinant of the folding rate for proteins with three-state folding kinetics

Oxana V. Galzitskaya, Sergiy O. Garbuzynskiy, Dmitry N. Ivankov, Alexei V. Finkelstein

Research output: Contribution to journalArticlepeer-review

136 Citations (Scopus)

Abstract

We demonstrate that chain length is the main determinant of the folding rate for proteins with the three-state folding kinetics. The logarithm of their folding rate in water (kf) strongly anticorrelates with their chain length L (the correlation coefficient being -0.80). At the same time, the chain length has no correlation with the folding rate for two-state folding proteins (the correlation coefficient is -0.07). Another significant difference of these two groups of proteins is a strong anticorrelation between the folding rate and Baker's "relative contact order" for the two-state folders and the complete absence of such correlation for the three-state folders.

Original languageEnglish
Pages (from-to)162-166
Number of pages5
JournalProteins: Structure, Function and Genetics
Volume51
Issue number2
DOIs
Publication statusPublished - 1 May 2003
Externally publishedYes

Keywords

  • Contact order
  • Folding nucleus
  • Protein folding kinetics
  • Protein size
  • Protein topology
  • Rate of folding
  • Three-state kinetics
  • Transition state
  • Two-state kinetics

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