Beilunmycin, a new virginiamycins antibiotic from mangrove-derived Streptomyces sp. 2BBP-J2 and the antibacterial activity by inhibiting protein translation

Zhong Ke Jiang, Xin Xin Hu, Lan Lin Xiao, Yi Ru Ren, Anna N. Shakhtina, Dmitrii A. Lukianov, Ilya A. Osterman, Petr V. Sergiev, Olga A. Dontsova, Hao Wang, Gang Wu, Xue Fu You, Cheng Hang Sun

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

One new virginiamycin derivative, ‘beilunmycin’ (1), and three known virginiamycin antibiotics, 16-hydroxy-virginiamycin M1 (2), virginiamycin M2 (3), and virginiamycin M1 (4), were isolated from the culture of a mangrove-derived endophytic Streptomyces sp. 2BBP-J2. The structures were characterized on the basis of their spectroscopic data, and the absolute configuration of 1 was established by ECD calculations. Compounds 1–4 exhibited antibacterial activities against Gram-positive bacteria, with MIC values in the range of 0.5–16 μg/ml. All the compounds demonstrated strong protein translation-stalling activity, with minimal concentrations detected with pDualrep2 in the range of 1.9–5.9 nmol.

Original languageEnglish
Pages (from-to)992-1000
Number of pages9
JournalJournal of Asian Natural Products Research
Volume23
Issue number10
DOIs
Publication statusPublished - 2021

Keywords

  • Mangrove-derivedStreptomyces
  • antibacterial activities
  • endophytic actinobacteria
  • new antibiotic
  • translation-stalling activity

Fingerprint

Dive into the research topics of 'Beilunmycin, a new virginiamycins antibiotic from mangrove-derived Streptomyces sp. 2BBP-J2 and the antibacterial activity by inhibiting protein translation'. Together they form a unique fingerprint.

Cite this